New tumour technique analysis

A new technique for analysing tumours called “representative sequencing” is reported in several papers this week. It could be available in the NHS within 3 years. It offers a means of more thorough analysis of a tumour and therefore more accurately identify the appropriate treatment. The results were published in the journal Cell Reports but a brief summary taken from the “i” newspaper is here

News from the Chestnut Unit

We asked our CNS what the impact of Covid-19 has been on the Unit. These answers we hope you will find helpful. Where possible clinics are carried out by phone. If you are invited into the Unit you will be telephoned 24 hours before the appointment to confirm that you are well enough to visit and are still willing to come into Derriford. Whether you are a new patient or an existing one you still arrive and leave the Unit by the single entrance but when you come in your temperature will be checked. Staff temperatures are checked daily. Staff and patients wear PPE where face to face contact is necessary.

Telephone clinics reduce footfall into the hospital, therefore reducing clinical risk for patients and staff.

For new patients
Assessments for bladder, kidney and prostate symptoms are still being carried out but results are given by phone and letter. For bladder cancer patients TUR-BTs are still being carried out but at Care-UK rather than Derriford. Pre op assessment along with COVID 19 swabs are done at Care UK. Bigger operations such as nephrectomies and cystectomies are still going ahead at Derriford. Pre op assessments/COVID 19 for these patients take place at Derriford. Lynher ward has moved. Post op patients are nursed on Stonehouse Ward at present.

For existing patients
Cystoscopies are still being carried out on time and in the Unit. BCG and mitocycin treatments are being administered only to high risk patients. Other treatments are deferred. Chemotherapy is being offered on a reduced service by Oncology which is operating out of the Nuffield Hospital across the road.

What contribution can patients make to saving lives? Follow the goverment advice and any directions of the hospital on your visit. Stay safe.

‘More cures, fewer side-effects’ with pioneering radiotherapy machine

The first patient in the UK has been treated with a pioneering new radiotherapy machine.

The MR Linac simultaneously scans tumours inside the body while delivering X-ray radiation beams.

It means clinicians can plan and adjust radiotherapy in real time, allowing it to be more accurate than ever before.

The team at the Institute of Cancer Research and the Royal Marsden Hospital in London describe the technology as “groundbreaking”.

They hope it will lead to more patients being cured while experiencing fewer side-effects.

Barry Dolling, 65, who has prostate cancer, is the first patient in the UK to be treated.

He told me: “I feel privileged and excited to be part of this. I volunteered to be part of the Prism trial and feel my treatment and the research will help others diagnosed with prostate cancer in the future.”


Prof Uwe Oelfke, who leads the joint MR Linac project at the ICR and Marsden, told me: “Ten years ago we did not think it would be possible to combine MRI and radiotherapy – this is a real step-change in technology.”

The machine has been specially designed so that the magnetic coils of the MRI and the X-ray beam of the linear accelerator do not interfere with each other.

It will be especially useful in treating tumours that shift in size and shape in the body, such as in the lung, bladder and bowel.

Dr Alison Tree, consultant oncologist at the Royal Marsden, described the new technology as “a dream come true” that would enable clinicians to deliver more targeted, higher doses of radiation, sparing healthy tissue.

“In lung cancer, we would like to give higher doses of radiotherapy but are limited because the tumour is often close to other vital structures in the chest,” she said.

“This allows us to see the cancer more clearly and make sure the radiation goes where it is needed and not where it can cause harm.”

Single treatment

The ability to give higher doses of radiation will enable patients to complete their treatment more quickly.

Mr Dolling will have 20 sessions of radiotherapy in the MR Linac. But it’s predicted that eventually it will be possible to cure some cancers in a single treatment.

The Royal Marsden will treat prostate, rectal, bowel, bladder, cervical and eventually lung cancer in the MR Linac.

The installation of the MR Linac was made possible by a £10m grant from the Medical Research Council, plus support from the Royal Marsden Cancer Charity.

A second machine, at the Christie in Manchester, will begin treating patients early next year.

Both hospitals are part of an international research consortium together with companies Elekta, which makes the MR Linac, and Phillips.

So far, the only other cancer centres to treat patients with the MR Linac are in the Netherlands, in Utrecht and Amsterdam.

The prospect of more accurately targeted radiotherapy, with fewer side-effects, will inevitably mean there will be high demand for access to treatment in the MR Linac.

Dr Tree said there would be several clinical trials and priority would be given to research that yielded the most benefit to patients.

There have been significant improvements in radiotherapy treatment in recent years – it already contributes to 40% of all the cases of cancer that are cured.

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